Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1
作者： Anne Kraemer , Zarko Barjaktarovic , Hakan Sarioglu , Klaudia Winkler , Friederike Eckardt-Schupp
DOI: 10.1371/JOURNAL.PONE.0077484
关键词:
摘要: Background microRNAs (miRNAs) are non-coding RNAs that alter the stability and translation efficiency of messenger RNAs. Ionizing radiation (IR) induces rapid selective changes in miRNA expression. Depletion processing enzymes Dicer or Ago2 reduces capacity cells to survive exposure. Elucidation critical radiation-regulated miRNAs their target proteins offers a promising approach identify new targets increase therapeutic effectiveness treatment cancer.
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