Detection of microRNA in urine to identify patients with endometrial cancer: a feasibility study

摘要: Objective To find dysregulated urinary microRNAs associated with endometrial cancer as a first step in finding non-invasive new diagnostic biomarker. The second objective is to determine the correlation of clinicopathological characteristics. Methods A prospective cohort study patients presenting abnormal bleeding between March and November 2019 was performed at Royal Cornwall Hospital Trust Truro. Urine samples were obtained from women diagnosed benign sampling. MicroRNA isolated quantitative real time PCR used detect expression levels microRNAs. Results total 61 included this study: 24 patients, 37 controls. Median age 64 years (range 45–94) median body mass index 29 kg/m2 17–54). MiR-223 significantly up-regulated urine cancers (p=0.003). Furthermore, let7-i, miR-34a, miR-200c down-regulated miR-424 obese women. In addition, miR-148a miR-222 elderly women, miR-16, miR-26b, deregulated multiple comorbidities. Conclusion can potentially be test for cancer. aberrant microRNA patient Further research larger trials needed validate potential utility