Studies of tissue NMR relaxation enhancement by manganese. Dose and time dependences

摘要: Manganese is a powerful paramagnetic material and potential NMR contrast agent. It drastically affects the properties of solutions tissues less toxic than most other transition elements. also possesses some unusual advantageous features; it alters T1 T2 to different degrees, can bind macromolecules become even more effective at reducing proton relaxation times. The dose dependence tissue rate increases has been measured in mice, enhancement ratios that describe binding effects have evaluated. These imply tenfold reduction manganese achievable when ion binds intracellular components, demonstrated such be major factor efficacy enhancement. effect on ratio T1/T2 dependent so lower doses may useful for imaging techniques. postmortem time course times organs containing varies between with content, demonstrates relationship metal content not simple correlation concentration since large variations occur water are fixed.