Continuous and low error-rate passive synchronization of pre-formed droplets
作者： O. J. Dressler , T. Yang , S.-I. Chang , J. Choo , R. C. R. Wootton
DOI: 10.1039/C5RA08044D
关键词:
摘要: A microfluidic droplet-handling architecture for the synchronization of asynchronous, mis-matched, pre-formed droplet streams is demonstrated. This shown to be robust variations in input frequencies, whilst still producing highly reliable synchronisation. The operational phase space with regards size disparity explored and long-term stability system confirmed. Specifically, platform synchronies at a rate 33 Hz over extended periods time an error less than 0.2%.
rsc.org
researchgate.net 
sci-hub.se 参考文章(58)
Rogier M. Schoeman, Evelien W.M. Kemna, Floor Wolbers, Albert van den Berg, High-throughput deterministic single-cell encapsulation and droplet pairing, fusion, and shrinkage in a single microfluidic device. Electrophoresis. ,vol. 35, pp. 385- 392 ,(2014) , 10.1002/ELPS.201300179
Piotr Garstecki, Irina Gitlin, Willow DiLuzio, George M. Whitesides, Eugenia Kumacheva, Howard A. Stone, Formation of monodisperse bubbles in a microfluidic flow-focusing device Applied Physics Letters. ,vol. 85, pp. 2649- 2651 ,(2004) , 10.1063/1.1796526
Lucas Frenz, Kerstin Blank, Eric Brouzes, Andrew D. Griffiths, Reliable microfluidic on-chip incubation of droplets in delay-lines Lab on a Chip. ,vol. 9, pp. 1344- 1348 ,(2009) , 10.1039/B816049J
Michele Zagnoni, Charles N. Baroud, Jonathan M. Cooper, Electrically initiated upstream coalescence cascade of droplets in a microfluidic flow. Physical Review E. ,vol. 80, pp. 046303- 046303 ,(2009) , 10.1103/PHYSREVE.80.046303
Todd Thorsen, Richard W. Roberts, Frances H. Arnold, Stephen R. Quake, Dynamic pattern formation in a vesicle-generating microfluidic device. Physical Review Letters. ,vol. 86, pp. 4163- 4166 ,(2001) , 10.1103/PHYSREVLETT.86.4163
Takasi Nisisako, Shiva A. Portonovo, Jacob J. Schmidt, Microfluidic passive permeability assay using nanoliter droplet interface lipid bilayers. Analyst. ,vol. 138, pp. 6793- 6800 ,(2013) , 10.1039/C3AN01314F
M. Prakash, N. Gershenfeld, Microfluidic Bubble Logic Science. ,vol. 315, pp. 832- 835 ,(2007) , 10.1126/SCIENCE.1136907
Andrew C. Hatch, Jeffrey S. Fisher, Armando R. Tovar, Albert T. Hsieh, Robert Lin, Stephen L. Pentoney, David L. Yang, Abraham P. Lee, 1-Million droplet array with wide-field fluorescence imaging for digital PCR Lab on a Chip. ,vol. 11, pp. 3838- 3845 ,(2011) , 10.1039/C1LC20561G
Eujin Um, Matthew E. Rogers, Howard A. Stone, Combinatorial generation of droplets by controlled assembly and coalescence. Lab on a Chip. ,vol. 13, pp. 4674- 4680 ,(2013) , 10.1039/C3LC50957E
Slawomir Jakiela, Wojciech Kamysz, Wioletta Baranska-Rybak, Douglas B. Weibel, Piotr Garstecki, Krzysztof Churski, Tomasz S. Kaminski, Rapid screening of antibiotic toxicity in an automated microdroplet system Lab on a Chip. ,vol. 12, pp. 1629- 1637 ,(2012) , 10.1039/C2LC21284F