The crossroads between cancer stem cells and aging

摘要: The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within tumour is responsible for the initiation and progression neoplasia. original best evidence existence CSCs came from advances in field haematological malignancies. Thus far, putative have been isolated various solid non-solid tumours shown to possess self-renewal, differentiation, regeneration properties. Although research progressing extremely fast, proof concept CSC still lacking key questions remain unanswered, e.g. origin these cells. Nevertheless, it undisputed neoplastic transformation associated with genetic epigenetic alterations normal cells, better understanding complex processes utmost importance developing new anti-cancer therapies. In present review, we discuss special emphasis on age-associated govern carcinogenesis, at least some types tumours. We scientific literature age-related leading main challenges field.