Alpha-interferon and fragility at 16q22
作者： Fiorella Shabtai , Isaac Halbrecht , Shlomo Bichacho , Jacob Hart , Jerry Orlyn
DOI: 10.1007/BF00273838
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摘要: Inducibility or enhancement of fragility at 16q22 by alpha-interferon has been found in a Danish laboratory and our laboratory. Several other studies were not able to confirm these findings. We present the results large study on peripheral blood lymphocytes 15 selected controls 146 patients treated vitro alpha-interferon. In some parallel with distamycin A performed. Both interferon induced same fragility, but only patients. agents consistently enhance spontaneously expressed fragility. is location metallothionein genes, whose transcription interferon. The induction gene however, do seem be directly related. To explain findings we advance hypothesis that may modification virus(es) selective tropism for cells which are differently influenced pleiotropic action
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