A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder.

摘要: As the treatability of syndrome autism becomes more possible there is a great deal interest in effectiveness various therapies. Although very influential nonmedical literature cited Autism Research Review International Newsletter finds that dimethylglycine (DMG) regarded as effective than usual psychopharmacologic drugs, have been no studies DMG using currently accepted research methodology. We report double-blind, placebo-controlled, crossover pilot study low dose and placebo sample eight autistic males ranging age from 4 years 5 months to 30 8 months, who completed full 3 1/2-month consisting drug-free baseline periods at beginning, end, in-between two, 1-month double-blind trials which or was given. Measures included Campbell-NIMH rating scale, an experimental individualized scale created for each child. Analysis all three scales revealed statistically significant differences, parent reports were equally distributed. The major methodologic weaknesses are thought be dosage small size.