Prevalence and associated factors of allergic rhinitis and atopic dermatitis in children.

摘要: Allergic disorders are the chronic diseases of greatest pediatric morbidity, affecting over 25 % population. Indeed, this situation has been referred to as an "allergic epidemic". In comparison with asthma, atopic dermatitis and allergic rhinitis have less extensively investigated, although does not mean that they should be regarded minor but rather alterations affect quality life patients their families, which generate considerable direct indirect costs. Despite important research effort, reason for epidemic is well known. These multifactor without a single causal agent, in most component genetic predisposition patient (atopy), modulated by environmental factors, exposure allergens, infections irritants, among others. A confounding element fact concept encompasses phenotypes rhinitis, or asthma no IgE-mediated mechanism demonstrated, can manifest way similar true phenotypes. Differentiation between two difficult establish on basis self-administered questionnaires alone, absence precise etiological diagnosis. The present article reviews numerous factors suggested responsible increase recorded last few decades, differences prevalence observed centres. For these results published literature contradictory, some cases due lack control associated interacting factors. Consensus exists only such established parallelism reduction infectious processes one hand, particles generated diesel fuel combustion other. addition, implicated could act differently (and even antagonically) upon atopy different disease phenotypes, thereby complicating study interactions further.