Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

摘要: The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score 13-15. Prognostic models that were developed predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed validate predicting 3-12-month Outcome Extended (GOSE) or PPCS in adults with TBI. analyzed data from the Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) project, which included 2862 TBI, 6-month GOSE available for 2374 Rivermead Post-Concussion Symptoms Questionnaire (RPQ) results 1605 participants. Model performance was evaluated based on calibration (graphically characterized by slope intercept) discrimination (C-index). validated five published three scores. used different cutoffs some measured 2 weeks post-injury. Discriminative ability varied substantially (C-index between 0.58 0.79). Corticosteroid Randomisation After Significant Head (CRASH) trial prediction <5 discriminated best 0.78 0.79), but poorly calibrated. performing 2-week 0.75 0.76). In conclusion, none prognostic early has both good persons future studies, should be tailored population relevant end-points readily predictors.