Inherited thrombophilia and pregnancy associated venous thromboembolism

摘要: Pulmonary embolism is the leading cause of maternal mortality in developed countries and accounts for 20% pregnancy related deaths United States.1 2 The risk pulmonary deep vein thrombosis, collectively known as venous thromboembolism, increased during further by presence inherited or acquired thrombophilias. We summarise epidemiology diagnosis thromboembolism discuss anticoagulant management women with thrombophilia who are at of, develop, postpartum period. #### Scenario A 30 year old woman, a heterozygote factor V Leiden mutation, presents eight weeks' gestation her first wondering whether she should receive prophylactic anticoagulation to prevent recurrent thrombosis pregnancy. Several years ago left leg after an ankle fracture prolonged immobilisation was found have mutation. treated anticoagulants three months, woman has had no thromboembolic events since stopping warfarin. Her mother surgery but did not undergo testing thrombophilia. #### Methods We searched Medline Cochrane database systematic reviews studies evaluating epidemiology, diagnosis, prevention, treatment period thrombophilia, using key words “venous thrombosis”, “deep “pulmonary embolism”, “pregnancy (complications)”, “thrombophilia”, “anticoagulants.” Venous occurs 10 per 100 000 childbearing age affects 100 pregnancies.3 Inherited present 30%-50% associated thromboembolism,3w1 being most frequently identified white population (table 1⇓). #### Non-inherited conditions that increase pregnancy ##### General conditionsw2