Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

摘要: Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at understanding molecular pathophysiology neuropathic have so far focused on a few known molecules and signaling pathways in neurons. However, appears to be very complex remains poorly understood. A global mechanisms involved needed for better treatment pain. Towards this end, we examined gene expression changes as well pathobiology cellular level spinal nerve ligation model using DNA microarray, quantitative real-time PCR immunohistochemistry. We found that behavioral hypersensitivity manifested persistent state accompanied previously undescribed expression. In DRG, regulation of: (1) immediate early genes; (2) genes such ion channels contribute excitability neurons; (3) are indicative secondary events neuroinflammation. addition, studied both injured uninjured DRG PCR, observed differential these two populations DRGs. Furthermore, demonstrated unexpected co-regulation many genes, especially activation neuroinflammation markers PNS CNS. The results our study provide new picture underlie complexity suggest chronic shares common with progressive neurodegenerative disease.