Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts

摘要: Osteoporosis is regarded as the most common chronic metabolic bone condition in humans. In osteoporosis, mesenchymal stem cells (MSCs) have reduced cellular function. Regenerative medicine using adipose-derived cell (ADSC) transplantation can promote growth and strength of new bones, improve stability, reduce risk fractures. Various methods been attempted to differentiate ADSCs functioning specialized for prospective clinical application. However, commonly used therapies resulted damage donor site morbidity, immune reactions, carcinogenic generation, postoperative difficulties. Photobiomodulation (PBM) improves ADSC differentiation proliferation along with reducing difficulties such treatment failures drug late initiation treatment. PBM a noninvasive, nonthermal that encourages produce more energy undergo self-repair by visible green red invisible near-infrared (NIR) radiation. The use has widely studied multiple outcomes observed due laser fluence wavelength dependence. this article, potential differentiating into osteoblasts various used, including biological induction, chemical PBM, will be addressed. Likewise, optimal parameters could ADSC, translating success, commented on.