Genomic sequencing of only tumor tissue could be misleading in nearly half of patients, study shows

作者: M. McCarthy

DOI: 10.1136/BMJ.H2036

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摘要: Clinicians who rely on genomic analysis of only a patient’s tumor tissue to guide cancer therapy could be misled by the presence harmless mutations that are also present in normal germline cells and unrelated cancer, study published Science Translational Medicine has found.1 Increasingly, it become standard practice perform sequencing identify cancer-causing responsible for development growth. Of particular interest clinicians “actionable genes” whose can help …

参考文章(1)
Siân Jones, Valsamo Anagnostou, Karli Lytle, Sonya Parpart-Li, Monica Nesselbush, David R. Riley, Manish Shukla, Bryan Chesnick, Maura Kadan, Eniko Papp, Kevin G. Galens, Derek Murphy, Theresa Zhang, Lisa Kann, Mark Sausen, Samuel V. Angiuoli, Luis A. Diaz, Victor E. Velculescu, Personalized genomic analyses for cancer mutation discovery and interpretation Science Translational Medicine. ,vol. 7, ,(2015) , 10.1126/SCITRANSLMED.AAA7161