Interaction Between Inflammatory State and Neurochemical Changes in Major Psychiatric Disorders

摘要: Inflammation is the immunological mechanism to react against danger signal. In old days, inflammation characterized by heat, redness, pain, swelling and loss of function in gross appearance inflammatory cells infiltration affected area microscopical appearance. Even though it not always possible demonstrate certain part brain patients with psychiatric disorders, there are evidences such as enhanced production mediators that indicated reaction immune system. It generally considered reactions occur response a signal abnormal cell death. With time, scientists both immunology neuroscience fields realized signals only due microorganisms, foreign bodies or tissue injury but also some noxious situations psychological emotional stress. The involvement system disorders is, fact, recognized since 1927 Wagner-Jauregg, psychiatrist who ever awarded Noble prize for his work on malaria inoculation treatment dementia paralytica (Raju, 1998) which was psychosis inducing fever, known ‘pyrotherapy’. That evidence activation induced infection could cure psychotic symptoms fever associated activation. On other hand meningitis toxic without reported Fischer, 1963. Taken together, field Medicine, relation between infection, inflammation, became interest early 20th Century. Around similar period, Biology, Selye (Selye, 1954) has neurogenic stress situation forcible immobilization effectively inhibit experimental granuloma-pouch under dorsal skin rat after chronic irritation cotton wool abolished adrenalectomized rats. finding anti-phlogistic effect suppression largely dependent secretion corticoids from adrenal glands. earliest starting point indicating although difficult conclude if