PRESCRIPTION OF CONTRAINDICATED AND INTERACTING DRUGS IN ELDERLY PATIENTS ADMITTED TO HOSPITAL

作者: Margot Gosney , Raymond Tallis

DOI: 10.1016/S0140-6736(84)90775-X

关键词:

摘要: 573 elderly patients admitted to the general medical and geriatric beds of a teaching hospital in January, 1983, were receiving an average 2.14 drugs on admission, 5.48 during inpatient stay, 3.47 discharge. Contraindicated or adversely interacting identified 200 (3.2%) 6160 prescriptions. 136 (23.7%) affected. 7 received which they had adverse reactions. There further 60 contraindicated 133 drugs. 117 prescriptions potentially hazardous another 27 interactions may have led suboptimal treatment. 131 (65.6%) undesirable deemed avoidable 36 (18%) probably so. The frequency errors was higher admission medication (5.3%) than (2.9%). importance, origin, prevention prescribing drug-induced morbidity are discussed.

参考文章(12)
Clement J. McDonald, Protocol-Based Computer Reminders, the Quality of Care and the Non-Perfectability of Man New England Journal of Medicine. ,vol. 295, pp. 1351- 1355 ,(1976) , 10.1056/NEJM197612092952405
Dean F. Davies, Nathan W. Shock, AGE CHANGES IN GLOMERULAR FILTRATION RATE, EFFECTIVE RENAL PLASMA FLOW, AND TUBULAR EXCRETORY CAPACITY IN ADULT MALES Journal of Clinical Investigation. ,vol. 29, pp. 496- 507 ,(1950) , 10.1172/JCI102286
C M Castleden, C F George, D Marcer, C Hallett, Increased sensitivity to nitrazepam in old age. BMJ. ,vol. 1, pp. 10- 12 ,(1977) , 10.1136/BMJ.1.6052.10
N. Hurwitz, Predisposing Factors in Adverse Reactions to Drugs BMJ. ,vol. 1, pp. 536- 539 ,(1969) , 10.1136/BMJ.1.5643.536
Ivan T. Borda, Assessment of Adverse Reactions Within a Drug Surveillance Program JAMA: The Journal of the American Medical Association. ,vol. 205, pp. 645- 647 ,(1968) , 10.1001/JAMA.1968.03140350055016
DE Tesh, L Beeley, Errors of drug prescribing. British Journal of Clinical Pharmacology. ,vol. 2, pp. 403- 409 ,(1975) , 10.1111/J.1365-2125.1975.TB00548.X
J. WILLIAMSON, JOAN M. CHOPIN, ADVERSE REACTIONS TO PRESCRIBED DRUGS IN THE ELDERLY: A MULTICENTRE INVESTIGATION Age and Ageing. ,vol. 9, pp. 73- 80 ,(1980) , 10.1093/AGEING/9.2.73
Russell K. Hulse, Stephen J. Clark, J. Craig Jackson, Homer R. Warner, Reed M. Gardner, Computerized medication monitoring system American Journal of Health-system Pharmacy. ,vol. 33, pp. 1061- 1064 ,(1976) , 10.1093/AJHP/33.10.1061
Cal W. Greenlaw, Darryl D. Zellers, Computerized drug-drug interaction screening system. American Journal of Health-system Pharmacy. ,vol. 35, pp. 567- 570 ,(1978) , 10.1093/AJHP/35.5.567
Nigef Paulet, Peter C. Bury, Manuel Needleman, Kenneth Raymond, Drug interactions: a study and evaluation of their incidence in Victoria. The Medical Journal of Australia. ,vol. 1, pp. 80- 81 ,(1982) , 10.5694/J.1326-5377.1982.TB132165.X