Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

作者: Wei Ding , Lei Shang , Ju-Fang Huang , Na Li , Dan Chen

DOI: 10.1186/S12868-015-0187-X

关键词:

摘要: Background Necroptosis is a type of regulated form cell death that has been implicated in the pathogenesis various diseases. Receptor-interacting protein 3 (RIP3), member RIP family proteins, reported as an important necroptotic pathway mediator regulating variety human diseases, such myocardial ischemia, inflammatory bowel disease, and ischemic brain injury. Our previous study showed RIP3 was expressed rat retinal ganglion cells (RGCs), where it significantly upregulated during early stage acute high intraocular pressure. Furthermore, expression co-localized with propidium iodide (PI)-positive staining (necrotic cells). These results suggested up-regulation might be involved necrosis injured RGCs. In this study, we aimed to reveal possible involvement oxygen glucose deprivation (OGD)-induced cell-5 (RGC-5) necroptosis.

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