Mode of action of beta receptor antagonists on cardiac muscle.

摘要: Abstract The effects of beta receptor antagonists (pronethalol and propranolol) on the intra-cellularly recorded cardiac action potential have been examined. These compounds did not alter resting potential, prolong (but in fact sometimes shortened) phase repolarization greatly reduced height rate rise contrast to effect sympathetic stimulation, which is increase potential. had previously demonstrated by several with known antiarrhythmic properties. prediction that pronethalol propranolol might local anesthetic has proved correct. significance intracellular discussed. It concluded interference potassium permeability explanation for but it due alterations sodium conductance excitation.