Factor viii zwitterionic polymer conjugates
作者： D. Victor Perlroth , James Aggen , Martin Linsell , Didier Benoit , Li Song
DOI:
关键词:
摘要: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
lens.org 参考文章(249)
Felix F Vajdos, Camellia W Adams, Timothy N Breece, Leonard G Presta, Abraham M de Vos, Sachdev S Sidhu, Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis Journal of Molecular Biology. ,vol. 320, pp. 415- 428 ,(2002) , 10.1016/S0022-2836(02)00264-4
A. Hye-Ryong Shim, H. Liu, P. J. Focia, X. Chen, P. C. Lin, X. He, Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 11307- 11312 ,(2010) , 10.1073/PNAS.1000806107
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Hans-Joachim Wallny, Bernhard Helk, Bernhardt L. Trout, Design and Application of Antibody Cysteine Variants Bioconjugate Chemistry. ,vol. 21, pp. 385- 392 ,(2010) , 10.1021/BC900509S
Nobuo Jo, Carolina Mailhos, Meihua Ju, Eunice Cheung, John Bradley, Kazuaki Nishijima, Gregory S. Robinson, Anthony P. Adamis, David T. Shima, Inhibition of Platelet-Derived Growth Factor B Signaling Enhances the Efficacy of Anti-Vascular Endothelial Growth Factor Therapy in Multiple Models of Ocular Neovascularization The American Journal of Pathology. ,vol. 168, pp. 2036- 2053 ,(2006) , 10.2353/AJPATH.2006.050588
Thomas M. Dillon, Margaret Speed Ricci, Chris Vezina, Gregory C. Flynn, Yaoqing Diana Liu, Douglas S. Rehder, Matthew Plant, Brad Henkle, Yu Li, Songpon Deechongkit, Brian Varnum, Jette Wypych, Alain Balland, Pavel V. Bondarenko, Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass Journal of Biological Chemistry. ,vol. 283, pp. 16206- 16215 ,(2008) , 10.1074/JBC.M709988200
Weifeng Lin, Hui Zhang, Jiang Wu, Zhen Wang, Haotian Sun, Jiang Yuan, Shengfu Chen, A novel zwitterionic copolymer with a short poly(methyl acrylic acid) block for improving both conjugation and separation efficiency of a protein without losing its bioactivity Journal of Materials Chemistry B. ,vol. 1, pp. 2482- 2488 ,(2013) , 10.1039/C3TB00474K
L. Ruiz, J.G. Hilborn, D. Léonard, H.J. Mathieu, Synthesis, structure and surface dynamics of phosphorylcholine functional biomimicking polymers Biomaterials. ,vol. 19, pp. 987- 998 ,(1998) , 10.1016/S0142-9612(97)00197-X
Rishard H. Chen, Chung-Jr Huang, Brian S. Newton, Gerd Ritter, Lloyd J. Old, Carl A. Batt, Factors affecting endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography. Protein Expression and Purification. ,vol. 64, pp. 76- 81 ,(2009) , 10.1016/J.PEP.2008.10.006
Jean-François Lutz, Ann Hoth, Preparation of Ideal PEG Analogues with a Tunable Thermosensitivity by Controlled Radical Copolymerization of 2-(2-Methoxyethoxy)ethyl Methacrylate and Oligo(ethylene glycol) Methacrylate Macromolecules. ,vol. 39, pp. 893- 896 ,(2006) , 10.1021/MA0517042
Jayakrishna Ambati, Benjamin J Fowler, None, Mechanisms of age-related macular degeneration Neuron. ,vol. 75, pp. 26- 39 ,(2012) , 10.1016/J.NEURON.2012.06.018