A Versatile A-ring Synthesis for Taxol

摘要: Careful A-ring substructure analysis for taxol has been carried out and a practical synthesis to all emergent substructures, viable as building blocks, developed. The starts from 2-methyl-l,3-cyclohexanedione enters via ketalized trimethylvinyltrit1ate trimethylester trimethylketoalcohol(s) with the hydroxyl group protected. give clear camprehensive survey af feasibility aur ap-