Synthesis of alkyl glycerophospholipids through 1-o-benzyl-2-o-methyl-rac-glycerol
作者： V. I. Shvets , A. N. Pinchuk , B. I. Mitsner
DOI: 10.1007/BF00766461
关键词:
摘要: l-O-Alkyl-2-O-methylglycero-3-phosphocholines are the synthetic analogs of natural alkyllysolecithins. They display high biological activity [13] and, especially importantly, selective cytotoxicity relative to tumor cells various etiologies. This property has been repeatedly confirmed both in experiments with cell cultures and experimental animals [3, 4, 6, ii, 15]. One most active (according literature data), l-O-octadecyl-2O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is undergoing clinical testing at present time [5, 6].
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