Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy

摘要: Background MicroRNAs (miRNAs) are short regulatory RNAs that control gene expression through interacting with the 3′UTR of target messenger RNAs. The purpose this study was to determine if circulating miRNAs useful biomarkers outcome in children dilated cardiomyopathy (DCM). Methods An array for 754 and real time polymerase chain reaction confirmation select were performed. Serum from 55 Results Two significantly up-regulated (hsa-miR-155 hsa-miR-636) 2 down-regulated (hsa-miR-646 hsa-miR-639) patients DCM who transplanted or died compared recovered their ventricular function. Receiver operator curves, performed differences any 1 these 4 differentially regulated recovered, resulted an area under receiver operating characteristic curve 0.875 Pre-Transplant blood draw point 0.93 day Transplant point. Conclusions We identified specific between need a transplant recover. A unique biomarker signature have potential recover would be valuable risk stratification challenging patient population.