Epidemiology of nonsyndromic conotruncal heart defects in Texas, 1999-2004.

摘要: INTRODUCTION: Congenital heart defects (CHDs) are the most common structural birth defects, yet their etiology is poorly understood. As there heterogeneity within group of CHDs, epidemiologic studies often focus on subgroups, conditions, such as conotruncal (CTDs). However, even these subgroups may be etiologic heterogeneity. The aim present study was to identify and compare maternal infant characteristics associated with three CTDs: truncus arteriosus (TA), dextro-transposition great arteries (d-TGA), tetralogy Fallot (TOF). METHODS: Data for cases nonsyndromic TA (n = 78), d-TGA 438), TOF 529) from Texas Birth Defects Registry, 1999–2004, were used estimate crude adjusted prevalence ratios, separately each condition, using Poisson regression. Polytomous logistic regression determine whether observed associations similar across two largest case groups (d-TGA TOF). RESULTS: In Texas, TA, d-TGA, 0.35, 1.98, 2.40 per 10,000 live births, respectively. There evidence a significant linear increase in risk condition advancing age (p < 0.01). Significant residence Texas-Mexico border; sex, race/ethnicity, history previous birth, year; race/ethnicity education. Further, some, but not all, variables significantly different TOF. CONCLUSION: These findings add our limited understanding epidemiology CTDs. Research (Part A), 2010. © 2010 Wiley-Liss, Inc.