Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)
作者： Xiao-Hui LV , Da-Zhao SHI
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摘要: The effects of levonorgestrel (LNG) on serum levels reproductive hormones and their receptor mRNA expression in the ovary uterus Mongolian gerbils were examined. results show that follicle-stimulating hormone (FSH) luteinizing (LH) increased, whereas estradiol (E2) progesterone (P4) decreased profoundly after LNG treatment. down-regulated (FSHR), (LHR), estrogen (ER) β (PR) ovary, ERα PR gerbils. time-dependent dose-dependent. had no obvious ovary. findings suggest impairs at molecular level Also, two ER subtypes may play different roles ERβ not be predominant subtype important sites action through its direct progesterone-like
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