The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis
作者： Youl-Nam Lee , Ha-Young Lee , Jae-Seok Kim , Cheol Park , Yung Hyun Choi
DOI: 10.1016/J.CANLET.2004.09.017
关键词:
摘要: We investigated the effect of novel phospholipase C activator, m-3M3FBS, on apoptosis leukemic cells. m-3M3FBS inhibited growth cell lines U937 and THP-1, but not primary monocytes. induced cells, which was accompanied by chromatin condensation DNA fragmentation. Moreover, m-3M3FBS-induced appeared to involve down-regulation anti-apoptotic Bcl-2, up-regulation pro-apoptotic Bax, release cytochrome c, caspase activation. cells also partly BAPTA-AM EGTA, indicating involvement intracellular calcium signaling in The results our study suggest that can be developed as a anti-leukemic agent.
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