Analysis of Prognostic Factors of Nasopharyngeal Carcinoma: Impact of in Situ Hybridization for Epstein-Barr Virus Encoded Small RNA 1:

摘要: OBJECTIVES: To evaluate the impact of clinical, histopathological, and molecular biological parameters on prognosis nasopharyngeal carcinoma (NPC).STUDY DESIGN AND SETTING: The clinical records 48 patients with a diagnosis NPC were retrospectively reviewed. In situ hybridization for Epstein-Barr virus encoded small RNA 1 (EBER-ISH) was applied 30 paraffin-embedded specimens available. Prognostic factors meticulously analyzed.RESULTS: EBER-ISH signal shown to be highly significant as favorable prognostic factor (P = 0.007). Although EBV more commonly associated Type III NPC, EBER-ISH-positive I-II had also significantly better survival rate than EBER-ISH-negative 0.036).CONCLUSIONS: addition WHO histopathological grade, 1997 UICC staging, nodal status, distant metastasis at presentation, factor.SIGNIFICANCE: This is first report describe EB...