Human Lateralization, Maternal Effects and Neurodevelopmental Disorders

摘要: In humans, behavioral laterality and hemispheric asymmetries are part of a complex biobehavioral system in which genetic factors have been repeatedly proposed as developmental determinants both phenomena. However, no model solely based on has proven conclusive, pushing towards the inclusion environmental epigenetic into system. Moreover, it should be pointed out that modulation might also account for why certain genes expressed differently parents offspring. Here, we suggest existence sensitive period early postnatal development, during exposure to postural motor lateral biases, interactive sensorimotor coordination with caregiver, canalizes lateralization "typical" direction. Despite newborns infants showing their own inherent asymmetries, canalizing effect context owes most adult caregivers (usually mother), whose infant-directed lateralized behavior specifically selected population-level trait, functional confer fitness particular, case left-cradling bias (LCB; i.e., predisposition mothers hold left side) represents an instance trait exhibiting heritability along maternal line, although investigation carried so far. Recent evidence, moreover, seems reduction this asymmetry is related several unfavorable conditions, including neurodevelopmental disorders. Future studies warranted understand whether how affect mother-infant interaction proneness offspring