Volatile anesthetics and second messengers in cardiac tissue.

摘要: The depression of myocardial contractility induced by volatile anesthetics is well documented in vivo and vitro studies. These agents’ direct depressant effect has been attributed to a decreased availability free intracellular calcium the contractile proteins sensitivity activation calcium. have shown depress slow inward currents sarcolemma, as inhibit uptake release sarcoplasmic reticulum.1 All these processes are modulated hormones, neurotransmitters other endogenous factors which regulate movements either directly or indirectly via second messenger system. Therefore, on homeostasis may be due interaction anesthetic with regulating secondary an action metabolic pathways modulating contractility.