Nonlinearity in human health response to ozone: Experimental laboratory considerations

摘要: Abstract Results from controlled laboratory exposures of human volunteers indicate that higher ozone (O 3 ) hourly average concentrations elicit a greater effect on hour-by-hour physiologic response (i.e., forced expiratory volume in 1 s [FEV 1 ]) than lower values, which implies nonlinear dose–response relationship. The current 8-h human-health O standard is not adequate for describing this FEV pattern response. Consequently, it recommended physiologically consistent sigmoidally shaped models based data be integrated into the air quality standard-setting process. model continuous, does require identification population threshold concentration, and deals with plateau considerations at high end distribution exposures. For developing to protect health, important identify those ambient-type concentration patterns adverse health effects. Such should ultimately only spirometric but other potentially impairment endpoints. Because paucity experimental results utilize regimes, additional studies are needed create database uses realistic variable regimes) studies. an can subsequently form level protective standard.