Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients.

作者: Angela Russell , Christopher Hahn , Sameer Chhibber , Lawrence Korngut , Nowell M. Fine

DOI: 10.1017/CJN.2020.271

关键词:

摘要: BACKGROUND Wild-type transthyretin amyloidosis (wtATTR) is an important cause of heart failure (HF); however, the prevalence and clinical significance neurologic complications remains uncertain. METHODS This analysis reports findings from a single-centre experience routine neuropathy screening at time wtATTR diagnosis by nerve conduction studies neurologist assessment, compared with age-matched controls. RESULTS Forty-one patients were included, 39 (95%) males, mean age 78.4 ± 7.7 years, 22 (54%) New York Heart Association (NYHA) class III-IV HF, along 15 controls (mean 77.1 4.2 80% male). Twenty-one (51%) diagnosed polyneuropathy, (37%) spinal stenosis, 36 (88%) carpal tunnel syndrome (CTS) 14 (34%) ulnar neuropathy. Comparison diagnoses among 1 (7%), 0, (7%) 3 (20%), respectively. Among NYHA 16 (73%) had polyneuropathy 5 (26%) I-II (p < 0.01), odds ratio 7.5 (95% confidence interval 1.9-29.9). After screening, 19 (46%) offered therapy and/or additional diagnostic evaluation. included CTS release surgery (16, 39%), neuropathic pain medication (3, 7%), block (1, 2%), wrist splinting (2, 5%) foot care 2%). Spine imaging was performed for patients, deltoid muscle sural biopsy (2%) patient. CONCLUSIONS Screening resulted in management change nearly half. CTS, common. approach warrants consideration as part assessment newly patients.

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