Excitability Blockers: Anticonvulsants and Low Concentration Local Anesthetics in the Treatment of Chronic Pain

摘要: The major use of anticonvulsants is in the treatment epileptic seizures. Local anesthetics are used primarily to block peripheral nerves for temporary anesthesia or diagnostic purposes temporarily relieve pain enable minor surgery. In recent years a new systemic administration local and has emerged: specific chronically painful conditions. This permits be rationally grouped together as specialized analgesics. While neither class drug clearly established analgesic efficacy most common pains, both can dramatically patients with severe neuropathic pain. weight evidence suggests that their effectiveness greatest those conditions associated abnormal neuronal discharge. basis this action appears correction pathophysiological disturbance initiated by neural injury. Specifically, they stabilize abnormally excitable nerve membranes.