The relationship of denosumab pharmacology and osteonecrosis of the jaws
作者： John Malan , Kyle Ettinger , Erich Naumann , O. Ross Beirne
DOI: 10.1016/J.OOOO.2012.08.439
关键词:
摘要: Denosumab is a new bone antiresorptive agent that has received approval by the Food and Drug Administration for use in patients with osteoporosis metastatic cancer to bones. Like bisphosponates are used as medications, denosumab been associated osteonecrosis of jaws (ONJ). However, because pharmacodynamics pharmacokinetics differ from bisphosphonates, ONJ related may resolve more rapidly drug holiday than bisphosphonate-related (BRONJ). This paper describes management patient who developed while receiving denosumab, reviews incidence compares pharmacology bisphosphonates. Because effects on turnover reversible quickly BRONJ.
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