Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation.

摘要: Aldosterone, the final product of renin-angiotensin-aldosterone system, is classically viewed as a regulator renal sodium and potassium handling, blood volume, pressure. Recent studies suggest that aldosterone can cause microvascular damage, vascular inflammation, oxidative stress endothelial dysfunction. In animal models, aldosterone-mediated injury in brain, heart, kidneys leads to stroke, myocardial injury, proteinuria. These effects may be modified by dietary salt intake; damage increased susceptible animals fed high-salt diet compared low-salt despite lower plasma levels on diet. humans, there growing literature supporting adverse heart failure, hypertension, left ventricular hypertrophy, disease. Aldosterone receptor antagonists are beneficial even patients angiotensin converting enzyme inhibitors attenuate mechanisms appear independent changes systolic This review focuses system describes our current understanding underlying for this injury.