Relative Roles of the Sympathetic and Parasympathetic Nervous Systems in the Reflex Control of Heart Rate

作者: GERALD GLICK , EUGENE BRAUNWALD , Robert M. Lewis

DOI: 10.1161/01.RES.16.4.363

关键词:

摘要: This study was designed to define the relative roles of sympathetic and parasympathetic nervous systems in reflex alterations heart rate consequent changes arterial pressure. In 23 experiments carried out on 22 anesthetized dogs studies performed four trained, unanesthetized dogs, acute pressure were produced by administering drugs acting peripheral vascular bed. The effects acutely elevating systemic also investigated intact human subjects. Augmenting above control levels with graded doses phenylephrine always slowed strikingly. Although complete blockade guanethidine or pronethalol did not significantly alter degree slowing, atropine vagotomy essentially abolished this response. Conversely, lowering intravenous injections nitroglycerin raised state, a response nethalide, but atropine. Thus, when rises control, decrease is mediated system, withdrawal activity playing no detectable role; falls below levels, elevation primarily system. These findings are consonant traditional concept which predicates simultaneous reciprocal occurring two components autonomic

参考文章(21)
B. GERNANDT, G. LILJESTRAND, Y. ZOTTERMAN, Efferent Impulses in the Splanchnic Nerve Acta Physiologica Scandinavica. ,vol. 11, pp. 230- 247 ,(1946) , 10.1111/J.1748-1716.1946.TB00343.X
Ancel Keys, Antonio Violante, THE CARDIO-CIRCULATORY EFFECTS IN MAN OF NEO-SYNEPHRIN (1-α-hydroxy-β-methylamino-3-hydroxy-ethylbenzene hydrochloride) 1 Journal of Clinical Investigation. ,vol. 21, pp. 1- 12 ,(1942) , 10.1172/JCI101270
Morris H. Nathanson, Harold Miller, Clinical observations on a new epinephrine-like compound, methoxamine. The American Journal of the Medical Sciences. ,vol. 223, pp. 270- 279 ,(1952) , 10.1097/00000441-195203000-00006
J.W. Black, J.S. Stephenson, PHARMACOLOGY OF A NEW ADRENERGIC BETA-RECEPTOR-BLOCKING COMPOUND (NETHALIDE) The Lancet. ,vol. 280, pp. 311- 314 ,(1962) , 10.1016/S0140-6736(62)90103-4
H. Weidinger, R. Hetzel, H. Schaefer, Aktionsströme in zentrifugalen vagalen Herznerven und deren Bedeutung für den Kreislauf Pfl�gers Archiv f�r die Gesamte Physiologie des Menschen und der Tiere. ,vol. 276, pp. 262- 279 ,(1962) , 10.1007/BF00362609
T. G. Brodie, A. E. Russell, On reflex cardiac inhibition The Journal of Physiology. ,vol. 26, pp. 92- 106 ,(1900) , 10.1113/JPHYSIOL.1900.SP000824
J.W Black, A.F Crowther, R.G Shanks, L.H Smith, A.C Dornhorst, A NEW ADRENERGIC: BETA-RECEPTOR ANTAGONIST The Lancet. ,vol. 283, pp. 1080- 1081 ,(1964) , 10.1016/S0140-6736(64)91275-9
C. Heymans, Reflexogenic Areas of the Cardiovascular System Perspectives in Biology and Medicine. ,vol. 3, pp. 409- 417 ,(1960) , 10.1353/PBM.1960.0038