Multiple Roles of Alu-Related Noncoding RNAs
作者： Audrey Berger , Katharina Strub
DOI: 10.1007/978-3-642-16502-3_6
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摘要: Repetitive Alu and Alu-related elements are present in primates, tree shrews (Scandentia), rodents have expanded to 1.3 million copies the human genome by nonautonomous retrotransposition. Pol III transcription from these occurs at low levels under normal conditions but increases transiently after stress, indicating a function of RNAs cellular stress response. assemble with proteins into ribonucleoprotein complexes can be processed smaller scAlu RNAs. play role regulating translation. They provide source for biogenesis miRNAs and, embedded mRNAs, targeted miRNAs. When as inverted repeats they become substrates editing enzymes, their modification causes nuclear retention mRNAs. Certain evolved unique units specific expression profiles producing highly functions.
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