Assessment on the antibacterial activity of nanosized silica derived from hypercoordinated silicon(IV) precursors

摘要: Silica nanoparticles were synthesized through a versatile sol–gel combustion method from hydrazide based hypercoordinated silicon complexes derived the reaction of tetrachloride with O-silylated derivatives. The characterized by 1H, 13C, 29Si NMR and ESI-mass spectrometric techniques. A refined morphology was observed in product after sintering i.e. spherical to rod shaped nanoparticles. powder X-ray diffraction patterns TEM images silica show formation IR spectra Si–O linkages DLS studies indicate particle size distribution be between 20 100 nm for material before 70–120 at 1000 °C. image decomposed gel indicates crystalline rods. This work also demonstrates influence nano-sized particles on antibacterial activity (DIZ, MIC MBC) better shown nano-rods than conventional TEOS (sol–gel) method. Experiments generation reactive oxygen species (ROS) oxidative stress demonstrate toxicity nanosilica particles.