Lung clearance index: Normal values, repeatability, and reproducibility in healthy children and adolescents

摘要: There is increasing interest in using the Multiple Breath Washout technique and lung clearance index (LCI) for detecting early pulmonary changes, example, cystic fibrosis disease. However, there are still limited data regarding equipment specific reference ranges, repeatability reproducibility. The aim of this prospective study was to assess within-test repeatability, short term reproducibility long reproducibility, establish normal values LCI healthy children adolescents sidestream ultrasonic flow sensor (EasyOne Pro, MBW Module, ndd Medical Technologies, Switzerland). Fourty-four volunteers (5.3-20.3 years) were recruited 1st test. Twenty-two out 44 measured on a 2nd test occasion after an interval 1 hr (2nd test). Thirty-four agreed come back follow up 6-15 months later (3rd Mean (SD) 6.2 (0.4), 6.3 6.0 (0.4) at 1st, 2nd, 3rd upper limit 7.0 all subjects. Within-test 5.1%. Short-term (1st vs. test) 4.2% with mean difference -0.13 (95% CI -0.350; 0.087). Long-term 5.1%, 0.017 -0.016; 0.348). With low variability both, within between tests, our demonstrates reliability robustness equipment, protocol analysis general. present will help interpret effect therapeutic interventions interpretation longitudinal patients diseases.