Absorption and passage of fat- and water-soluble thiamin derivatives into erythrocytes and cerebrospinal fluid of man

摘要: Oral administration of the lipid-soluble allithiamins, thiamin propyl disulfide and tetrahydrofurfuryl disulfide, caused a significant increase in activity whole blood, red blood cells, cerebrospinal fluid equivalent to that produced by parenteral, water-soluble hydrochloride pyrophosphate. In contrast, oral administra- tion thiamins did not significantly elevate biological fluids: this was probably due their rate-limited intestinal transport. The odor limits its usefulness multivitamins food fortification. Thiamin is odorless therefore more useful for such purposes. Orally administered allithiamin vitamers are recommended prophylaxis treatment deficits because they have same properties as parenterally thiamins. Am. J. C'lin. Nutr. 27: 676-680, 1974.