Biochemical and molecular aspects of the coagulation cascade.

作者: Earl W Davie

DOI: 10.1055/S-0038-1642645

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摘要: One of the early proposals for the initiation ofblood coagulation as a series of stepwise interactions with plasma proteins was published in 1962 by Oscar Ratnoff and myself (1)(Fig. l). According to this mechanism, Hageman factor (factor XII) was converted to activated Hageman factor in the presence of a glass surface andit, in turn, converted plasma thromboplastin antecedent

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