Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study

摘要: In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three which isolated disease. Comparative analysis positive and negative showed no difference in ALK positivity, immunophenotype, presence B symptoms or other sites The lymphohistiocytic variant was over represented the group (36% vs. 5%). With multi-agent chemotherapy, including high dose methotrexate, Ara-C intrathecal treatment, event free overall survival at 5 years were 50% (95%CI, 25-75%) 74% (45-91%), respectively with a median follow up 4.1 years.