Advances in nanowire transistors for biological analysis and cellular investigation

摘要: Electrical biosensors based on silicon nanowire field-effect transistors (SiNW-FETs) have attracted enormous interest in the biosensing field. SiNW-FETs proven to be significant and efficient detecting diverse biomolecular species with advantages of high probing sensitivity, target selectivity, real-time recording label-free detection. In recent years, advances been achieved, particularly for cellular investigation biomedical diagnosis. this critical review, we will report latest developments discuss advancements innovative designs SiNW-FET devices. This review introduces basic instrumental setup working principle SiNW-FETs. Technical approaches that attempted enhance detection sensitivity selectivity sensors are discussed. terms applications, achievements investigations protein–protein interaction, DNA/RNA/PNA hybridization, virus detection, recording, biological kinetics, clinical addition, novel architecture devices highlighted studies live neuron cells, electrophysiological measurements other signal transduction pathways. Despite these remarkable achievements, certain improvements remain necessary device performance applications FET-based biosensors; thus, several prospects about future development transistor-based instruments employments discussed at end review.