Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men.

摘要: Objectives: To study the effects of two different mixtures main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects intervention: Seventy-one healthy males aged 31-69y received one following treatments: (1) mixture 50% c9,t11 t10,c12 (CLA 50:50); (2) 80% 20% 80:20); (3) sunflower oil fatty acids (reference). The treatments were given as supplements in softgel capsules providing a total 1.7 g (c9,t11 + t10,c12) (50:50) or 1.6 glycerides (80:20) per day treatment groups for 12 weeks. Results: Almost twice many subjects reached protective antibody levels to hepatitis B when consuming CLA50:50 (15/24, 62%) compared with reference substance (7/21, 33%, P=0.075). In 80:20 this was 8/22 (36%). Other aspects function, ie DTH responses, NK cell activity, lymphocyte proliferation production TNF-α, IL1-β, IL6, IFN-γ, IL2, IL4, PGE2, not affected. Conclusion: This is first that suggests may beneficially affect initiation specific response vaccination. seen 50:50, but group. Chemicals/CAS: acylglycerol, 64706-27-0; gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; acid, 1509-85-9, 2197-37-7, 60-33-3, 822-17-3; prostaglandin E2, 363-24-6; oil, 8001-21-6; Dinoprostone, Hepatitis Antibodies; Vaccines; Interferon Type II, Interleukins; Linoleic Acid, 2197-37-7; Tumor Necrosis Factor-alpha