Increasing the sustainability of membrane processes through cascade approach and solvent recovery—pharmaceutical purification case study

摘要: Membrane processes suffer limitations such as low product yield and high solvent consumption, hindering their widespread application in the pharmaceutical fine chemicals industries. In present work, authors propose an efficient purification methodology employing a two-stage cascade configuration coupled to adsorptive recovery unit, which addresses two limitations. The process has been validated on of active ingredient (API) from genotoxic impurity (GTI) using organic nanofiltration (OSN). model system selected for study comprises roxithromycin macrolide antibiotic (Roxi) with 4-dimethylaminopyridine (DMAP) ethyl tosylate (EtTS) API GTIs, respectively. By implementing membrane diafiltration, was increased 58% 95% while maintaining less than 5 ppm GTI final solution. Through this enhancement, “revamped” unfeasible highly competitive unit operation when compared other traditional processes. advantage size exclusion membranes over separation techniques illustrated by simultaneous removal GTIs different chemical classes. addition, step assessed charcoal non-selective adsorbent, it shown that pure can be recovered permeate. Considering costs solvent, charcoal, waste disposal, concluded 70% is cost-optimum point. Conventional single-stage diafiltration (SSD) (TSD) configurations were terms green metrics cost, mass intensity, energy consumption. It calculated implementation TSD, depending batch scale, achieve up 92% cost saving reducing intensity 73%. revealing 96% reduction distillation CO2 footprint.