作者: Jens Schletter , Holger Heine , Artur J. Ulmer , Ernst T. Rietschel
DOI: 10.1007/BF02529735
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摘要: Endotoxin (lipopolysaccharide, LPS), a constitutent of the outer membrane cell wall gramnegative bacteria, exerts wide variety biological effects in humans. This review focuses on molecular mechanisms underlying these activities and discusses structure-function relationships endotoxin molecule, its interaction with humoral cellular receptors involved activation, transmembrane intra-cellular signal transduction pathways.