Quantitative Assay of Dopamine Receptor Subtypes

摘要: Dopamine, acting as a neurotransmitter in the central nervous system, is involved regulation of variety behaviors man and animals. Studies carried out over last decade have shown that not all responses attributed to release dopamine are mediated through same kind receptor. Cools Van Rossum (1976) first proposed existence two types receptors for an attempt explain results obtained studies effects apomorphine on stereotypy locomotor activity. However, precise pharmacological characterization difficult if only behavioral models utilized. Biochemical stimulation can result, some tissues, increase accumulation cyclic AMP activation dopamine-sensitive adenylate cyclase (Kebabian Greengard, 1971). Not receptors, however, appear act increases levels.