Regulation of MT1-MMP activity by β-catenin in MDCK non-cancer and HT1080 cancer cells
作者： Ping Liu , Jianbo Yang , Jing Pei , Duanqing Pei , Michael J. Wilson
DOI: 10.1002/JCP.22292
关键词:
摘要: Past studies on β-catenin in cancer cells focused nuclear localized and its involvement the Wnt pathway. Our goal here was to investigate function of both cytoplasm nucleus regulation MT1-MMP expression activity. We found that MDCK non-cancer inhibited cell surface localization MT1-MMP, thus proteolytic activity pro-MMP2 activation, via direct interaction with 18-amino acid cytoplasmic tail cytoplasm. In contrast, HT1080 enhanced by entering activating transcription factor Tcf-4/Lef, elevating level protein. also enhancement growth 3-D/2-D type I collagen gels migration were cells, whereas these functions cells. addition, involved E-cadherin Wnt-3a Taken together, our results present a differential effect versus These differences most probably due different subcellular locations pathways
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