Asymmetric syntheses of protected (2S,3S,4S)-3-hydroxy-4-methylproline and 4′-tert-butoxyamido-2′-deoxythymidine
作者： Wei-Hua Meng , Tian-Jun Wu , Hong-Kui Zhang , Pei-Qiang Huang
DOI: 10.1016/J.TETASY.2004.10.030
关键词:
摘要: Abstract Described herein is a versatile approach to (i) (2S,3S,4S)-3-hydroxy-4-methylproline 3, constituent of echinocandins and related oligopeptide antibiotics; (ii) (2S,3S)-3-hydroxyproline 1; (iii) (2R,3S)-3-hydroxyprolinol 5, (iv) 4′-tert-butoxyamido-2′-deoxythymidine 6b. The method features stepwise regio- diastereoselective reductive furylation the protected (3S,4S)-4-methylmalimide 10, (S)-malimide 9, chemoselective oxidative transformation furyl group carboxyl as key steps.
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