Folding Mechanism of Beta-Hairpin Trpzip2: Heterogeneity, Transition State and Folding Pathways
作者： Yi Xiao , Changjun Chen , Yi He
DOI: 10.3390/IJMS10062838
关键词:
摘要: We review the studies on folding mechanism of β-hairpin tryptophan zipper 2 (trpzip2) and present some additional computational results to refine picture heterogeneity pathways. show that trpzip2 can have a two-state or multi-state pattern, depending whether it folds within native basin through local state basins high-dimensional free energy surface; Trpzip2 fold along different pathways according packing order pairs. also point out important problems related still need clarification, e.g., wide distribution computed conformations for transition ensemble.
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