Systematic review: the epidemiology and clinical features of travellers' diarrhoea.

摘要: Summary Background  Travellers’ diarrhoea is the most common medical complaint among persons venturing into developing areas from industrialized regions. Aim  To review recent developments dealing with microbiological, clinical, pathophysiological and therapeutic aspects of travellers’ diarrhoea. Methods  The author’s extensive file plus a publications listed in PubMed on January 22, 2009 topic were reviewed. Results  largely caused by detectable undetected bacterial enteropathogens, explaining remarkable effectiveness antibacterial agents prophylaxis therapy illness. A number host genetic polymorphisms have been recently linked susceptibility to diarrhoea. Novel antisecretory are being developed for treatment considering their physiological effects acute All travellers should be armed one three drugs, ciprofloxacin, rifaximin or azithromycin, before trips use self occur during travel. Loperamide may treat milder forms can employed drugs. Conclusions  Diarrhoea will continue plague international high-risk regions. More studies incidence rate, relative important various pathogens geographical region world, risk factors optimal approach needed.