Secretogranin III : a Bridge between Core Hormone Aggregates and the Secretory Granule Membrane

摘要: Secretory granules in endocrine cells selectively store bioactive peptide hormones and amines, which are secreted a regulated manner upon appropriate stimulation. In addition to substances, various proteins lipids characteristic of secretory likely recruited restricted space at the trans-Golgi Network (TGN), then matures granule. Although experimental findings so far have strongly suggested that aggregation- receptor-mediated processes essential for formation granules, putative link between these two remains be clarified. Recently, secretogranin III (SgIII) has been identified as specific binding protein chromogranin A (CgA), representative constituent core aggregate within it was later revealed SgIII can also bind cholesterol-rich membrane domain TGN. Based on its multifaceted properties, may act central player platforms. Upon platforms, granule biogenesis coordinately occur; is, selective recruitment prohormones, processing modifying condensation mature an aggregate. This review summarizes theoretical concepts issue date focuses role cells.