Oxidative Stress in β-Thalassemia

摘要: Cell oxidative status, which represents the balance between oxidants and antioxidants, is involved in normal functions. Under pathological conditions, there a shift toward oxidants, leading to stress, cytotoxic, causing oxidation of cellular components that result cell death organ damage. Thalassemia hereditary hemolytic anemia caused by mutations globin genes cause reduced or complete absence specific chains (commonly, α β). Although stress not primary etiology thalassemia, it mediates several its pathologies. The main causes thalassemia are degradation unstable hemoglobin iron overload-both stimulate production excess free radicals. symptoms aggravated include increased hemolysis, ineffective erythropoiesis functional failure vital organs such as heart liver. status each patient affected multiple internal external factors, including genetic makeup, health nutrition, physical activity, age, environment (e.g., air pollution, radiation). In addition, influenced clinical manifestations disease (unpaired chains, overload, anemia, etc.). Application personalized (theranostics) medicine principles, diagnostic tests for selecting targeted therapy, therefore important optimal treatment these patients. We summarize role current potential antioxidative therapeutics β-thalassemia describe some methodologies, mostly cellular, might be helpful application theranostics approach therapy.